17q12 Kennisbankdeletion syndrome · static snapshot
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Gen–kenmerk-koppeling Klachten & kenmerken 59 ondersteunende bronnen vertrouwen 97% nieuwheid 63%

Het gen HNF1B komt in 30 artikelen samen met tumoutrisico voor

In 30 onafhankelijke artikelen komt het gen HNF1B samen met tumoutrisico voor. Associatiesterkte 0.17..

Hoe dit tot stand kwam

Gelijktijdig voorkomen is een *waarneming over de literatuur*, geen bewijs van oorzakelijkheid.

Gegenereerd 2026-11-13, laatst gewijzigd vandaag. Dedup-sleutel assoc:HNF1B:cancer. De engine controleert dit inzicht bij elke analyse opnieuw; als meer bronnen het eens zijn, stijgen zijn onderbouwing en vertrouwen en verschijnt het opnieuw als “nieuw”.

Bewijs (4 citaten)

…some 22. Courtesy of Kristin Andersen, Oslo University Hospital-Radiumhospitalet. In addition to the Philadelphia chromosome, several other important tumor-associated chromosomal abnormalities were identified during the pre-banding period. In 1963, Lele, Penrose and Stallard reported a visible deletion o…
…east. Lymphovascular invasion (LVI) and histologic grade are clinical parameters of high prognostic value in breast cancer and indicate the level of tumor aggressiveness. Many studies have focused on the association of breast cancer subtypes with gene expression and chromosomal profiles, but considerabl…
…e derived is a 58-year-old female diagnosed with moderately differentiated primary lung adenocarcinoma. Immunohistochemistry of the patient's primary tumor showed positive staining for thyroid transcription factor 1 (TTF1) and Napsin A. Pleural effusion was collected from the patient at the Molecular Dia…
…sms by which inherited genetics facilitate cancer initiation might transit through its cooperation with specific somatic events that then dictate the tumor features. Through a germline-somatic tandem leading to steroid biosynthesis, we suggest a paradigm to study cancer initiation. Abstract The biologica…

Ondersteunende documenten (56)

DocumentBronGepubliceerdGezienRelevantie
17q12 Recurrent Deletion Syndrome in Childhood pmc 2025-01-01 gisteren 1.00
Renal and Extrarenal Phenotypes in Patients With HNF1B Variants and... pmc 2024-01-01 gisteren 1.00
A Korean Family Presenting with Renal Cysts and Maturity-Onset Diab... pmc 2024-01-01 gisteren 1.00
HNF1B Transcription Factor: Key Regulator in Renal Physiology and P... pmc 2024-01-01 gisteren 1.00
A Case of Diabetes Mellitus Type MODY5 as a Feature of 17q12 Deleti... pmc 2024-01-01 gisteren 1.00
De novo HNF1 homeobox B mutation as a cause for chronic, treatment-... pubmed 2018-01-01 gisteren 1.00
Cross-Cancer Pleiotropic Associations with Lung Cancer Risk in Afri... pubmed 2019-04-01 gisteren 1.00
School level of children carrying a HNF1B variant or a deletion. pubmed 2020-01-01 gisteren 1.00
The Clinical Characteristics and Gene Mutations of Maturity-Onset D... pubmed 2022-01-01 gisteren 1.00
Extensive germline-somatic interplay contributes to prostate cancer... pubmed 2022-11-28 gisteren 1.00
Hepatocyte nuclear factor 1B deletion, but not intragenic mutation,... pubmed 2024-01-01 gisteren 1.00
Large Kidney Cysts in HNF1B Nephropathy Mimicking Autosomal Dominan... pubmed 2024-01-01 gisteren 1.00
Genetics of Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome: advance... pubmed 2024-01-01 gisteren 1.00
The computational analysis of tumor cell sensitivity to supertarget... pubmed 2026-03-01 gisteren 0.79
HNF1B-MODY (MODY-5): a rare form of diabetes with multisystemic fea... pubmed 2026-01-01 gisteren 1.00
Loss of Hnf1b in differentiated proximal tubule cells uncovers neph... pubmed 2026-08-13 gisteren 1.00
From Exome to Optical Mapping: Resolving a Complex 17q12 Rearrangem... pubmed 2026-10-09 gisteren 1.00
Navigating Genetic Testing in Nephrology: Options and Decision-Maki... pmc 2024-01-01 gisteren 1.00
Distinct chromosome abnormality patterns for differential diagnosis... pmc 2025-01-01 gisteren 1.00
Multi- and Transgenerational Histological and Transcriptomic Outcom... pmc 2025-01-01 gisteren 0.97
Comparative Copy Number Variation Profiling of GL01, an Immortalize... pmc 2025-01-01 gisteren 1.00
Case Report: Unraveling complex genomic alterations in a case of ch... pmc 2025-01-01 gisteren 1.00
A Case of Amyotrophic Lateral Sclerosis With Coexisting Maturity-on... pmc 2025-01-01 gisteren 1.00
MODY5 and 17q12 Microdeletion Syndrome: Phenotype Variability, Pren... pmc 2025-01-01 gisteren 1.00
Localization of potential tumor suppressor loci to a < 2 Mb region ... pubmed 1995-10-05 gisteren 1.00
Germline–Somatic Liaison Dictates Cancer Subtypes via de novo Stero... pmc 2025-01-01 gisteren 1.00
HER-2/neu and topoisomerase IIalpha in breast cancer. pubmed 2003-04-01 gisteren 0.99
Molecular Landscape of Acute Myeloid Leukemia in Pediatric Patient-... pmc 2025-01-01 gisteren 1.00
Building a human pluripotent stem cell-based gonadal niche: improvi... pmc 2025-01-01 gisteren 0.97
Lymphovascular invasion and histologic grade are associated with sp... pubmed 2015-03-01 gisteren 1.00
The Genetic Landscape of Müllerian Duct Anomalies: A Comprehensive Review pmc 2025-01-01 gisteren 1.00
Subtype distribution, clinical presentation, and molecular spectrum... pmc 2025-01-01 gisteren 1.00
From mutation to symptoms: a multi-center study on HNF1B -related n... pmc 2025-01-01 gisteren 1.00
HNF1B variant without hyperglycaemia as a cause of isolated profoun... pubmed 2023-02-09 gisteren 1.00
Chromosome instability region analysis and identification of the dr... pubmed 2023-11-01 gisteren 1.00
The Genetic Landscape and Precision Medicine in Neonatal Diabetes M... pmc 2026-01-01 gisteren 1.00
Structural variations in evolutionary novel genomic regions: new in... pmc 2026-01-01 gisteren 1.00
A complex microdeletion 17q12 phenotype in a patient with recurrent... pubmed 2012-05-14 gisteren 1.00
Case Report: Nephrocalcinosis from pancreatic hypoplasia in HNF1B d... pmc 2026-01-01 gisteren 1.00
Pediatric Hepatocyte Nuclear Factor 1B ( HNF1B ) Disease: Diabetes ... pmc 2025-01-01 gisteren 1.00
A novel inversion at 17q12 disrupting HNF1B gene in a patient with ... pmc 2026-01-01 gisteren 1.00
Hepatic dysfunction, hyperuricemia, and multiple renal cysts in ado... pmc 2026-01-01 gisteren 1.00
Transient neonatal diabetes mellitus as an early diagnostic clue to... pmc 2026-01-01 gisteren 1.00
Functional validation of a non-canonical HNF1B splice-site variant in MODY5 pmc 2026-01-01 gisteren 1.00
Cancer Cytogenetics: Deep Roots, New Branches in the Age of Omics pmc 2026-01-01 gisteren 1.00
Molecular impact of a novel HNF1B missense variant in childhood-ons... pmc 2026-01-01 gisteren 1.00
BART-spatial unravels biologically significant transcriptional regu... pmc 2026-01-01 gisteren 0.76
HNF1B-MODY in the Norwegian MODY Registry and the Norwegian Childho... pmc 2026-01-01 gisteren 1.00
HNF1B-MODY (MODY-5): a rare form of diabetes with multisystemic fea... pmc 2026-01-01 gisteren 1.00
HNF1B -related disease: developmental origins, molecular mechanisms... pmc 2026-01-01 gisteren 1.00
Asymmetric attrition and secondary chromosome destabilization after... pmc 2026-01-01 gisteren 1.00
Clinical Spectrum and Early Renal Functional Variability in a Natio... pmc 2026-01-01 gisteren 1.00
Precision Medicine in Pediatric Nephrology: From Shared Clinical Ph... pmc 2026-01-01 gisteren 1.00
Genetic Insights into Pediatric Polycystic Kidney Disease and Overl... pmc 2026-01-01 gisteren 1.00
Molecular characterization of HER2-negative breast cancers reveals ... pubmed 2025-02-01 gisteren 1.00
PMC12903773 local_files - gisteren 1.00