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New publication Genes & inheritance 1 supporting source confidence 97% novelty 75%

Thyroxine binding globulin deficiency due to a novel HNF1B gene variant in a young girl with high thyroxine requirement

Primary hypothyroidism is managed with oral levothyroxine (LT4) using a daily dose of 1.5 to 2 µg per kg. Elevated thyroid-stimulating hormone (TSH) despite a high dose of LT4 is a common problem and could be due to multiple etiologies, including poor drug compliance, thyroxine (T4) malabsorption, celiac disease, and consumptive hypothyroidism.

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How this was derived

Indexed from **openalex** on 2026-11-13 (relevance 1.00, tier peer_reviewed).

Generated 2026-11-13, last changed yesterday. Dedup key newdoc:514. The engine re-checks this insight on every analysis run; if more sources agree, its corroboration and confidence go up and it reappears as “new”.

Evidence (1 quote)

Thyroxine binding globulin deficiency due to a novel HNF1B gene variant in a young girl with high thyroxine requirement peer_reviewed · published 2026-09-03 · live page
Thyroxine binding globulin deficiency due to a novel HNF1B gene variant in a young girl with high thyroxine requirement Abstract Primary hypothyroidism is managed with oral levothyroxine (LT4) using a daily dose of 1.5 to 2 µg per kg.

Supporting documents (1)

ArticleSourcePublishedSeenRelevance
Thyroxine binding globulin deficiency due to a novel HNF1B gene var... openalex 2026-09-03 yesterday 1.00