Gene–trait link
kidney and urinary tract
56 supporting sources
confidence 97%
novelty 62%
LHX1 appears alongside kidney and urinary tract in 40 sources
Across the collected corpus, the gene LHX1 co-occurs with kidney and urinary tract in 40 independent documents (of 45 documents mentioning LHX1 and 241 mentioning kidney and urinary tract). Association strength 0.17.
How this was derived
Co-occurrence is an *observation about the literature*, not proof of causation: it says these topics are discussed together in the sources we hold.
Generated 2026-11-13, last changed
today. Dedup key assoc:LHX1:kidney.
The engine re-checks this insight on every analysis run; if more sources agree, its corroboration and confidence go up and it reappears as “new”.
Evidence (4 quotes)
Genetic Insights into Pediatric Polycystic Kidney Disease and Overlapping Ciliopathies: A Narrative Review
peer_reviewed
· published 2026-01-01
· live page
…30; Accepted 2026 Oct 8; Collection date 2026 Oct. 1. Introduction Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited renal disorder and the leading genetic cause of chronic kidney disease (CKD) in adulthood. Based on comprehensive European registry and population sequenci…
The Importance of Molecular Testing in the Diagnosis of Genetic Syndromes with Chronic Kidney Disease: Genotype–Phenotype Correlations
peer_reviewed
· published 2026-01-01
· live page
…00 genes are associated with hereditary kidney disease, which may manifest as isolated kidney issues or as part of a syndrome that also includes extrarenal manifestations. The aim of this study was to identify genetic variants in a group of ten patients who presented with clinical signs suggestive of gen…
Hepatocyte nuclear factor 1 in renal lipid metabolism: molecular mechanisms and therapeutic potentials
peer_reviewed
· published 2025-01-01
· live page
…ng author. Contributed equally. Abstract Kidney disease is increasingly linked to dysregulated lipid metabolism, yet the molecular mechanisms driving renal lipotoxicity remain poorly understood. This review elucidates the pivotal role of the hepatic nuclear factor-1 family (HNF-1α and HNF-1β) in renal li…
Long-Read Sequencing in CKD Diagnostics: Breaking Genomic Barriers and Expanding Global Inclusion
peer_reviewed
· published 2026-01-01
· live page
…e of genetics in the assessment of CKD cases, stressing the need for thorough family history evaluations, consideration of the age of CKD onset, extrarenal symptoms, and the inclusion of genetic testing in the diagnostic process. 36 This review examines the current and emerging role of LRS in the diagnos…