Phenotype expansion
kidney and urinary tract
1 supporting source
confidence 97%
novelty 90%
New observation reported: Discussion This is the first report to identify and validate the function of a transcription enhancer in the k…
A source describes a new or expanded observation: “Discussion This is the first report to identify and validate the function of a transcription enhancer in the kidney that controls dimorphic Klotho expression.”
How this was derived
Flagged by novelty language (“for the first time”, “expands the phenotype”, …) in pubmed.
Generated 2026-11-13, last changed
yesterday. Dedup key expansion:390cc3.
The engine re-checks this insight on every analysis run; if more sources agree, its corroboration and confidence go up and it reappears as “new”.
Evidence (1 quote)
Sexually dimorphic renal expression of mouse Klotho is directed by a kidney-specific distal enhancer responsive to HNF1b.
peer_reviewed
· published 2024-09-14
· live page
Discussion This is the first report to identify and validate the function of a transcription enhancer in the kidney that controls dimorphic Klotho expression.
Supporting documents (1)
| Document | Source | Published | Seen | Relevance |
|---|---|---|---|---|
| Sexually dimorphic renal expression of mouse Klotho is directed by ... | pubmed | 2024-09-14 | yesterday | 1.00 |